Why You Should Ask Your Doctor About BYSTOLIC

There are many reasons to talk to your doctor about taking BYSTOLIC (nebivolol) to help lower your blood pressure.

  • Shown to reduce blood pressure in over 10 clinical trials in more than 4,000 patients
  • Can be used alone or in combination with certain other medications to help reduce blood pressure
  • Once-daily medication with a blood pressure–lowering effect that lasts for a 24-hour period
  • A low incidence of side effects. In studies with BYSTOLIC, the 5 most common side effects were headache, fatigue, dizziness, diarrhea, and nausea

Results from BYSTOLIC Clinical Trials

When studied in multiple clinical trials, BYSTOLIC was shown to reduce blood pressure in adults when it was used alone or when it was taken with certain other blood pressure–lowering medications.

In clinical trials with patients treated with BYSTOLIC alone,

At 12 weeks, BYSTOLIC (20 mg) lowered systolic blood pressure (the top number) by as much as
and lowered diastolic blood pressure (the bottom number) by as much as
12
mm Hg
 
11
mm Hg

In these trials, placebo (sugar pill) lowered systolic blood pressure (the top number) by as much as
and lowered diastolic blood pressure (the bottom number) by as much as
5
down-arrow
mm Hg
 
5
down-arrow
mm Hg

In these trials BYSTOLIC (5 mg) lowered systolic blood pressure by 10 mm Hg and diastolic blood pressure by 10 mm Hg. BYSTOLIC (10 mg) lowered systolic blood pressure by 11 mm Hg and diastolic blood pressure by 10 mm Hg.

Who is Prescribed BYSTOLIC?

BYSTOLIC is for adults with stage I or stage II* hypertension (high blood pressure) to help lower their blood pressure. Lowering blood pressure can help reduce the risk of fatal and nonfatal cardiovascular events, primarily strokes and heart attacks.

BYSTOLIC was shown to provide blood pressure reductions when it was used alone or when it was taken with certain other blood pressure–lowering medications. Tell your doctor about any medications you are taking or planning to take, including, but not limited to, antiarrhythmics, antidepressants, other beta blockers, digitalis, or calcium channel blockers, and discuss the potential for interactions.

*Stage 1: systolic (top number) between 130 and 139 mm Hg or diastolic (bottom number) between 80 and 89 mm Hg.
Stage 2: systolic (top number) 140 mm Hg or higher or diastolic (bottom number) 90 mm Hg or higher.

What are the possible side effects of BYSTOLIC?

The most common side effects people taking BYSTOLIC report are headache, fatigue (tiredness), dizziness (if you feel dizzy, sit or lie down and tell your doctor right away), diarrhea, nausea, insomnia (difficulty falling or staying asleep), chest pain, bradycardia (slow heartbeat), dyspnea (shortness of breath), rash, and peripheral edema (leg swelling due to fluid retention). Other possible side effects include masking (hiding) the symptoms of low blood sugar and hyperthyroidism (overactive thyroid), especially a fast heartbeat. Tell your doctor if you gain weight or have trouble breathing while taking BYSTOLIC.

This is not a complete list of side effects. Tell your doctor if you have any side effects that bother you or don’t go away.

Remember, with any medication, it is important to discuss with your doctor any potential obstacles in your treatment plan and how to address them. Do not suddenly stop taking your medication or alter your dose without your doctor’s knowledge and guidance.

If your doctor has prescribed BYSTOLIC for your high blood pressure, it’s important that you take it every day exactly as your doctor tells you. Be sure you know how you may react to this medication before operating automobiles, using machinery, or engaging in other tasks requiring alertness. Consult your physician if you experience difficulty in breathing. You should tell your physician about all the medicines you are taking and if you are diabetic or taking medicines to treat diabetes.

Tell your doctor about any medical conditions, including those affecting your kidney or liver.

Learn how best to take this once-daily medication.

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DOWNLOAD THE DOCTOR DISCUSSION GUIDE

Are you at risk or currently taking medication for high blood pressure? Use this guide to help you talk to your doctor.*

*This Doctor Discussion Guide is provided to assist you with discussions with your healthcare provider only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.

INDICATIONS AND IMPORTANT RISK INFORMATION


What is BYSTOLIC?

BYSTOLIC is a prescription medicine that belongs to a group of medicines called “beta blockers.” BYSTOLIC is used, often with other medicines, to treat adults with high blood pressure (hypertension). BYSTOLIC is not approved for use in children under 18 years of age.

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Important Risk Information about BYSTOLIC
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Important Risk Information
Important Risk Information about BYSTOLIC
Who should NOT take BYSTOLIC?

Do not take BYSTOLIC if you:

  • Have heart failure and are in the ICU or need medicines to keep up your blood circulation.
  • Have a slow heartbeat or your heart skips beats (irregular heartbeat)
  • Have severe liver damage
  • Are allergic to any ingredient in BYSTOLIC. The active ingredient is nebivolol.
What should I tell my healthcare provider before taking BYSTOLIC?

Before starting BYSTOLIC, tell your healthcare provider about all of your medical conditions, including if you:

  • Have asthma or other lung problems (such as bronchitis or emphysema)
  • Have problems with blood flow in your feet and legs (peripheral vascular disease). BYSTOLIC can make symptoms of blood flow problems worse.
  • Have diabetes and take medicine to control blood sugar
  • Have thyroid problems
  • Have liver or kidney problems
  • Have had allergic reactions to medications or have allergies
  • Have a condition called pheochromocytoma (rare adrenal gland tumor)
  • Are pregnant or trying to become pregnant. It is not known if BYSTOLIC is safe for your unborn baby. Talk with your doctor about the best way to treat your high blood pressure while you are pregnant.
  • Are breastfeeding. It is not known if BYSTOLIC passes into your breast milk. You should not breastfeed while using BYSTOLIC.
  • Are scheduled for surgery and will be given anesthetic agents
  • Have had acute angina (symptoms include chest pain or discomfort) or an MI (heart attack) as BYSTOLIC has not been studied in patients with these conditions.

Also, to avoid a potentially serious or life-threatening condition, tell your healthcare provider if you are taking or plan to take any prescription or over-the-counter medications, vitamins, or herbal products, including:

  • Certain CYP2D6 inhibitors (such as some antiarrhythmics like quinidine or propafenone or certain antidepressants such as fluoxetine or paroxetine, etc).
  • Other beta blockers
  • Digitalis
  • Certain calcium channel blockers (such as verapamil and diltiazem)
  • Antiarrhythmic agents (such as disopyramide)
What are the possible side effects of BYSTOLIC?

The most common side effects people taking BYSTOLIC report are headache, fatigue (tiredness), dizziness (if you feel dizzy, sit or lie down and tell your doctor right away), diarrhea, nausea, insomnia (difficulty falling or staying asleep), chest pain, bradycardia (slow heartbeat), dyspnea (shortness of breath), rash, and peripheral edema (leg swelling due to fluid retention). Other possible side effects include masking (hiding) the symptoms of low blood sugar and hyperthyroidism (overactive thyroid), especially a fast heartbeat. Tell your doctor if you gain weight or have trouble breathing while taking BYSTOLIC.

This is not a complete list of side effects. Tell your doctor if you have any side effects that bother you or don’t go away.

What other information do I need to know about taking BYSTOLIC?
  • Do not stop taking BYSTOLIC suddenly. You could have chest pain or a heart attack. If your doctor decides that you should stop taking BYSTOLIC, he or she will lower your dose slowly and over time.
  • Take BYSTOLIC every day exactly as your doctor tells you. Your doctor will tell you how much BYSTOLIC to take and how often. Your doctor may start with a low dose and raise it over time.
  • Do not stop taking BYSTOLIC or change your dose without talking with your doctor.
  • BYSTOLIC can be taken with or without food.
  • If you miss a dose, take your dose as soon as you remember, unless it is close to the time to take your next dose. Do not take 2 doses at the same time. Take your next dose at the usual time.
  • If you take too much BYSTOLIC, call your doctor or poison control center right away.
What is BYSTOLIC?

BYSTOLIC is a prescription medicine that belongs to a group of medicines called “beta blockers.” BYSTOLIC is used, often with other medicines, to treat adults with high blood pressure (hypertension). BYSTOLIC is not approved for use in children under 18 years of age.

What is High Blood Pressure (Hypertension)?

Blood pressure is the force in your blood vessels when your heart beats and when your heart rests. You have high blood pressure when the force is too great.

High blood pressure makes the heart work harder to pump blood through the body and causes damage to the blood vessels. BYSTOLIC tablets can help your blood vessels relax so your blood pressure is lower. Medicines that lower your blood pressure lower your chance of having a stroke or heart attack.